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用途
AMG-510是一种KRAS G12C抑制剂,由于它中断了蛋白质信号传导,因此导致KRAS G12C肿瘤消退。
用途 一种有效的、口服生物可利用的、选择性的KRAS G12C共价抑制剂。
AMG-510 is a potent KRAS G12C covalent inhibitor. AMG-510 selectively targets the KRAS p.G12C mutant, at either the DNA, RNA or protein level, and prevents, through an as of yet not elucidated manner, expression of and/or tumor cell signaling through the KRAS p.G12C mutant. This may inhibit growth in KRAS p.G12C-expressing tumor cells.
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